Observations on the Urinary Excretion of Sulfadiazine.

نویسندگان

  • O L Peterson
  • R A Goodwin
  • M Finland
چکیده

Although the kidney is the main excretory channel for the sulfonamide drugs' as well as the site of some of the most serious complications resulting from their use, the factors influencing their excretion have received less attention than they deserve. Marshall, Emerson, and Cutting (1) concluded from their studies on dogs that increasing the rate of urine flow apparently increased the renal clearance of sulfanilamide. Their findingwas subsequently supported by the work of Stewart, Rourke, and Allen (2) in human subjects. On the other hand, Alyea, Daniel, and Yates (3) and later Lucas and Mitchell (4) presented data which they interpreted as showing that sulfanilamide is excreted at a constant rate, irrespective of the urine volume. Bullowa and his coworkers (5) found, in patients, that sulfapyridine is excreted at an irregular rate which is independent of the rate of urine flow. Clearance rates of the various sulfonamide derivatives has indicated considerable degrees of tubular reabsorption (1, 6 to 12). The clinical impression is prevalent that excretion of sulfapyridine, sulfathiazole, and sulfadiazine can be hastened by "forcing fluids," and the procedure is usually recommended in patients who are exhibiting toxic effects from these drugs. There are no adequate data, however, to support this impression. In this paper are presented the results of attempts by various procedures to induce diuresis of drug and of urine in persons receiving sulfadiazine in ordinary therapeutic doses. An increase in the rate of excretion of drug may be of some advantage in patients who are exhibiting severe systemic reactions, such as drug rashes, fevers, or agranulocytosis. Water diuresis, on the other hand, would obviously be desirable in patients who manifest urinary tract irritation as a result of the precipitation of the drug. It was the purpose of this study to determine which of the procedures in common use most effectively produces these two results, either separately or simultaneously. MATERIALS AND METHODS

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

24-HOUR URINARY CALCIUM EVALUATION IN A HEALTHY POPULATION SAMPLE AND IN PATIENTS WITH UROLITHIASIS

A study was designed to evaluate the normal value of 24 hr urinary calcium levels in the city of Yazd. The average urinary excretion of calcium in a sample of 329 persons randomly selected was 232 mg/day, while patients with a history of recurrent urolithiasis excreted 20X mg/day. There is evidence which shows that more important factors than the amount of urinary calcium exist which influe...

متن کامل

Study on the effect of high calcium intake on serum protein bound iodine and urinary excretion of iodine

  Iodine deficiency remains a major health problem in the world, including some parts of Iran. It has been recognized that there is usually a close and inverse relationship between iodine in the soil and water and presence of endemic goiter. Calcium has been suggested as one of goitrogens, though the definite role, extent and mechanism particularly in human have not been studied. Serum protein-...

متن کامل

تعیین مقدار تولید پروتئین میکروبی با استفاده از مشتقات بازهای پورینی دفع شده در ادرار شترهای یک کوهانه تغذیه شده با مقادیر مختلف سلمکی ساقه سفید

The aim of present experiment was to measure endogenous urinary purine derivatives using feed restriction method, as well as to determine the effect of 4 levels feeding on microbial protein synthesis. The present experiments was conducted by four camels about 326 Kg body weight.  The camels were fed by different level of Atriplex leucoclada (AL), including maintenance, 1.25, 1.5 times of mainte...

متن کامل

Diuretic Activity of Sufoof-E-Suzak Qawi an Unani Polyherbomineral Formulation

The Suffof-e-Suzak Qawi is an unani polyherbomineral formulation and is being used in the alternative system of medicine for its anti-gonorrheal and diuretic activity. It is an official monograph in national formulary of unani medicine-NFUM and reported as anti-gonorrheal and diuretic. The aqueous suspension of the formulation was studied for its possible diuretic activity, effect on urinary so...

متن کامل

Effects of Methanolic Extract of Oxystelma esculentum on Diuresis and Urinary Electrolytes Excretion in Rats

The diuretic activity of methanol extract of Oxystelma esculentum aerial parts (MEOE) was studied in male Wister albino rats at 5h and 24h interval. The animals were divided into 5 groups: control, urea, furosemide and 200mg/kg and 400mg/kg MEOE. The extract was administered intraperitoneally (i.p) pretreated and all animals were saline MEOE. The urine volume (in mL) and electrolytes excretio...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of clinical investigation

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 1943